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Identification of cancer stem cells provides novel tumor models for drug discovery
Douglas D. Fang, Danyi Wen, Yajun Xu
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 112-121 doi: 10.1007/s11684-012-0199-1
Cancer stem cells (CSCs) have received considerable attention from the research community since theybecoming increasingly important for eradicating CSCs in heterogeneous tumor masses and to cure the cancer
Keywords: cancer stem cell tumor model drug discovery
Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 462-476 doi: 10.1007/s11684-013-0270-6
Keywords: drug resistance cancer stem cell checkpoint kinase 1 (CHK1) PF-00477736 lung cancer tumorigenicity
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 361-373 doi: 10.1007/s11684-018-0656-6
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantrole in both development and cancer progression.Depending on the contextual signals and intracellular gene circuits of a particular cell, this programThese cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistanceand the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and
Keywords: epithelial-to-mesenchymal transition cancer metastasis cancer stem cell
The unregulated commercialization of stem cell treatments: a global perspective
Douglas Sipp
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x
Keywords: stem cell tourism medical ethics stem cell policy and regulation alternative medicine
The regulatory sciences for stem cell-based medicinal products
Bao-Zhu Yuan,Junzhi Wang
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 190-200 doi: 10.1007/s11684-014-0323-5
Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.
Keywords: stem cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines
Therapeutic potential of stem cell in liver regeneration
Jinzheng LI, Min LI, Bolin NIU, Jianping GONG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 26-32 doi: 10.1007/s11684-011-0107-0
Keywords: stem cell liver disease regenerative medicine
Stem cell niches and endogenous electric fields in tissue repair
Li LI, Jianxin JIANG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z
Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
Keywords: stem cell stem cell niche electric field tissue repair
Transcriptomics and proteomics in stem cell research
Hai Wang,Qian Zhang,Xiangdong Fang
Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11684-014-0336-0
Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.
Keywords: embryonic stem cells transcriptomics proteomics
Xiaodong Mo, Xiaojun Huang
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 306-315 doi: 10.1007/s11684-013-0279-x
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide
Keywords: partially matched related donor hematopoietic stem cell transplantation allogeneic
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 227-239 doi: 10.1007/s11684-021-0896-8
Keywords: cannabidiol depression radial neural stem cells neurogenesis
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 239-247 doi: 10.1007/s11684-011-0123-0
Keywords:
hematopoietic stem cell
hematopoiesis
Yuting Tan,Han Liu,Saijuan Chen
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 412-420 doi: 10.1007/s11684-015-0423-x
Keywords: preleukemic stem cell acute myeloid leukemia relapse DNMT3A
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 356-371 doi: 10.1007/s11684-011-0159-1
Keywords: gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 6-10 doi: 10.1007/s11684-007-0002-x
Keywords: available observable neuroregeneration protection function reconstruction
Title Author Date Type Operation
Identification of cancer stem cells provides novel tumor models for drug discovery
Douglas D. Fang, Danyi Wen, Yajun Xu
Journal Article
Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line
Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Journal Article
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
Journal Article
The unregulated commercialization of stem cell treatments: a global perspective
Douglas Sipp
Journal Article
The regulatory sciences for stem cell-based medicinal products
Bao-Zhu Yuan,Junzhi Wang
Journal Article
Therapeutic potential of stem cell in liver regeneration
Jinzheng LI, Min LI, Bolin NIU, Jianping GONG
Journal Article
Stem cell niches and endogenous electric fields in tissue repair
Li LI, Jianxin JIANG
Journal Article
Transcriptomics and proteomics in stem cell research
Hai Wang,Qian Zhang,Xiangdong Fang
Journal Article
Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation
Xiaodong Mo, Xiaojun Huang
Journal Article
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
Journal Article
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
Journal Article
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property
Yuting Tan,Han Liu,Saijuan Chen
Journal Article
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancercell proliferation and
Journal Article
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Journal Article